BioChemistry > QUESTIONS & ANSWERS > WGU C785 Biochemistry Unit Exam Questions & Answers Latest 2021/2022 (All)

WGU C785 Biochemistry Unit Exam Questions & Answers Latest 2021/2022

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Which level of protein structure is disrupted through the hydrolysis of peptide bonds? Quaternary Tertiary Primary Secondary Correct Answer- Primary The primary structure of a protein is the seq... uence of amino acids held together by peptide bonds. Peptide bonds are formed by dehydration reactions and disrupted by hydrolysis. A mutation in the beta-hemoglobin gene, which results in the replacement of the amino acid glutamate in position 6 with the amino acid valine, leads to the development of sickle cell anemia. The structures of glutamate and valine are shown below. If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so that the valine in position 6 was replaced with a different amino acid, which replacement for valine would be expected to have the best clinical outcome, in theory, for the patient? (Assume the valine can potentially be replaced with any amino acid other than glutamate.) Correct Answer- The original amino acid in a healthy patient is glutamate, which is negatively charged. The mutated amino acid is valine, which is non-polar. Valine is causing sickle cell anemia. The best amino acid to replace valine so that the patient is healthy again would be the one most like glutamate, so any negatively charged amino acid. Secondary, tertiary, and quaternary levels of protein structure can all be impacted by exposing a protein to which treatment? [Show More]

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