Chemotherapy Certification Exam (Latest 2023/2024) Complete Solution Doxorubicin - Answer -Cardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRA ... VASATION OCCURS= cool/ice + Totect Idamycin - Answer -Cardiotoxic (cardiomyopathy) Bleomycin - Answer -AVOID oxygen supplementation Methotrexate - Answer -*Leukovorin decreases cytotoxicity* Pemetrexed - Answer -Vitamin B12 & folic acid supplements to decrease toxicity Fludarabine - Answer -Immunosuppression Thioguanine - Answer -Bone Marrow Suppression Stomatitis/Mucositis 5-FU - Answer -*Stomatitis Bone marrow depression *Diarrhea Mucositis Capeticibine - Answer -***Pro-drug that converts 5FU in liver Stomatitis & mucositis Palmar-plantar erythrodysthesias (hand foot syndrome) Cytarabine or Cytosine Arabinoside - Answer -Cerebellar neurotoxicity Gemcitabine - Answer -Radiosensitizer DO NOT GIVE W/ RADIATION, except at very low doses Carmustine - Answer -***Solvent is alcohol Alcohol sensivity is an issue Mix ONLY in 0.9% NaCl Carboplatin - Answer -Dose by CALVERT formula Allergic reaction increased from 1-27% in pts receiving >6-7 courses Cisplatin - Answer -Renal toxicity Kidney protection w/ fluids & sometimes AMIFOSTINE MONITOR MAGNESIUM levels Oxaliplatin - Answer -NEUROTOXICITY AVOID COLD (neuropathies exacerbated by cold exposure) Dilute with D5W* [Show More]
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