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NR 566 Week 4 Study Outline .Latest 2020/21

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NR 566 Week 4 Study Outline .Latest 2020/21.NR566 Week 4 Study Outline Many questions are written to assess your clinical application of the material from the textbook, in real-world scenarios. Chapter 25: Drugs Use ...

NR 566 Week 4 Study Outline .Latest 2020/21.NR566 Week 4 Study Outline Many questions are written to assess your clinical application of the material from the textbook, in real-world scenarios. Chapter 25: Drugs Used in Treating Inflammatory Processes (p. 801-834 only) • Know the pharmacodynamics, pharmacotherapeutics clinical use, drug interactions and adverse drug reactions for: • Non-steroidal anti-inflammatory drugs (NSAIDs) o pharmacotherapeutics clinical use ▪ NSAIDS inhibit cyclo-oxygenase (COX-1 and COX-2) activity, thus inhibiting prostaglandin synthesis. ▪ COX-1 is present in all tissues and cells, especially platelets; endothelial cells; the GI tract; and renal microvasculature, glomeruli, and collecting ducts. ▪ COX-2 is an "inducible" enzyme that is synthesized mainly in response to pain and inflammation. ▪ NSAIDs are primarily used for their anti-inflammatory activity but are also effective analgesics for the relief of mild to moderate pain ▪ Absorption • Rapidly absorbed after oral administration • Food delays absorption. ▪ Metabolism • NSAIDs are metabolized by liver and excreted in urine. • Acetaminophen is metabolized by liver. • When acetaminophen is taken regularly or in large doses, the stores of glutathione become depleted and hepatic necrosis may occur. ▪ Clinical use: • Rheumatoid arthritis o Use NSAID or celecoxib to reduce joint pain and swelling. o Follow American College of Rheumatology suggestions for treatment. o Increased risk for complications, so monitor closely • Osteoarthritis o Acetaminophen or NSAIDs can be used for pain. • Gout o Indomethacin, naproxen, and sulindac • Mild to moderate pain o Nonopioid analgesia includes NSAIDs and acetaminophen. o Ibuprofen and naproxen most commonly used • Primary dysmenorrhea o NSAIDs (ibuprofen or naproxen) are drugs of choice. • Tendonitis and bursitis o Indomethacin SR, naproxen, and sulindac • Fever o Ibuprofen is drug of choice. • Drug of choice for mild to moderate pain in o Pregnancy o Patients with history of GI bleed o Aspirin allergy, blood coagulation disorders, upper GI disease • Drug of choice for fever o Above adults o Children o Especially children with fever during flu-like illness

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