Immunology > A-Level Question Paper > Immunology exam 3.pdf (All)

Immunology exam 3.pdf

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1. Successful testing of the pre-TCR induces all of the following, except: a. Allelic exclusion b. Rearrangement of alpha, gamma, and delta c. Expression of Ig-alpha and Ig-beta d. Expression of C... D4 and CD8 2. During negative selection, a B cell receives a signal indicating that its receptor binds to self with strong affinity. What options does the B cell have at this point? a. Try again at rearrangement of the heavy chain b. Move to the cortex for positive selection c. Seek positive selection from FDC d. Try again at rearrangement of the light chain 3. Deficiency in which of the following molecules would result in a clinical presentation of no B cells and no antibodies, but other cell populations are normal? a. BTK b. AID c. RAG1 d. Tdt e. CD3 4. What is the goal of receptor editing in B cells? a. To reduce affinity forself b. To enhance affinity forself MHC c. To increase affinity for FDC d. To ensure that the cells are MHC-restricted 5. A T cell binds with high affinity to MHC class II displayed by thymic cortical epithelial cells. Which of the following would not occur as an immediate result of this? a. The cell would receive a signal to become a CD4 T cell b. The cell would immediately undergo apoptosis c. The cell would move on to negative selection d. The would pass positive selection 6. Which of the following happens third during the T cell life cycle? a. Expression of CD4 only b. Pre-TCR expression c. Positive selection d. Exit the bone marrow e. Rearrangement of beta, gamma, and delta 7. Which of the following happens last during the T cell life cycle? a. Expression of CD2 b. Rearrangement of beta, gamma, and delta c. Negative selection d. Expression of CD4 and CD8 e. Rearrangement of alpha, gamma, and delta 8. Which of the following happens second during the B cell life cycle? a. Affinity maturation / b. Pre-BCR expression c. Negative selection d. Co-expression of IgM and IgD e. Interaction with FDC [Show More]

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