ESSENTIAL CELL BIOLOGY, FOURTH EDITION
CHAPTER 16: CELL SIGNALING
© 2014 GARLAND SCIENCE PUBLISHING
General Principles of Cell Signaling
16-1 Cell lines A and B both survive in tissue culture containing serum but do
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ESSENTIAL CELL BIOLOGY, FOURTH EDITION
CHAPTER 16: CELL SIGNALING
© 2014 GARLAND SCIENCE PUBLISHING
General Principles of Cell Signaling
16-1 Cell lines A and B both survive in tissue culture containing serum but do not proliferate.
Factor F is known to stimulate proliferation in cell line A. Cell line A produces a receptor
protein (R) that cell line B does not produce. To test the role of receptor R, you introduce
this receptor protein into cell line B, using recombinant DNA techniques. You then test all
of your various cell lines in the presence of serum for their response to factor F, with the
results summarized in Table Q16-1.
Table Q16-1
Which of the following cannot be concluded from your results above?
(a) Binding of factor F to its receptor is required for proliferation of cell line A.
(b) Receptor R binds to factor F to induce cell proliferation in cell line A.
(c) Cell line A expresses a receptor for factor F.
(d) Factor F is not required for proliferation in cell line B.
16-2 For each of the following sentences, fill in the blanks with the best word or phrase
selected from the list below. Not all words or phrases will be used; each word or phrase
should be used only once.
Cells can signal to each other in various ways. A signal that must be relayed to the entire
body is most efficiently sent by __________________ cells, which produce hormones
that are carried throughout the body through the bloodstream. On the other hand,
__________________ methods of cell signaling do not require the release of a secreted
molecule and are used for very localized signaling events. During __________________
signaling, the signal remains in the neighborhood of the secreting cell and thus acts as a
local mediator on nearby cells. Finally, __________________ signaling involves the
conversion of electrical impulses into a chemical signal. Cells receive signals through a
__________________, which can be an integral membrane protein or can reside inside
the cell.
amplification G protein phosphorylation
contact-dependent K+ channel receptor
endocrine neuronal target
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