Anti-inflammatory Drugs
NSAIDS (ATI 279) – inhibits cyclooxygenase 1 & 2 : suppresses inflammation, relieves pain
Ibuprofen
Salicylates (Aspirin)
Acetaminophen (Tylenol)
Respiratory System Drugs
4 illnesses or
...
Anti-inflammatory Drugs
NSAIDS (ATI 279) – inhibits cyclooxygenase 1 & 2 : suppresses inflammation, relieves pain
Ibuprofen
Salicylates (Aspirin)
Acetaminophen (Tylenol)
Respiratory System Drugs
4 illnesses or diseases that impact URT and LRT? COPD, asthma, pneumonia
Upper Respiratory Tract
CARDIOVASCULAR!!
CARDIAC PART 1
Classification for Hypertension (JNC 8/9)
Sexual dysfunction is common in antihypertensive drug use
Pregnancy: NO beta blockers in 1st trimester; NO ARBs or ACE Inhibitors
*Diuretics
Prototypes: Lasix (Black Box warning, makes you hypovolemic-really know BP and HR)
-BB WARNING: water and electrolyte depletion and severe diuresis, makes you hypovolemic
-TREATS PULM. EDEMA FROM HF, HYPERCALCEMIA, HTN
• Hydrochlorothiazide – LESS risk of losing electrolytes bc of location
-drug of choice for people with hypertension plus diabetes or plus heart failure
-never do and ARB with an ACE together, it’s always either or
-check apical pulse always beforehand for a full minute (hold medication if below 60 beats/min)
BB WARNING- instruct pts not to stop the drug suddenly (1-2 weeks gradually), fatal arrhythmias
-can exacerbate CHF
DIGOXIN!!! (Lanoxin) Know every damn thing about it
Most often used drug to treat heart failure as second line medication
Digibind is an antidote for life-threatening overdose, decrease dose for mild overdose
-dont give IM, give orally or IV slowly with dilution
*treat hypokalemia before digoxin (3 hrs after IV), same with hyperkalemia. K has to be normal
D-D Interactions: ALOT
Class IV antiarrhythmics include two calcium-channel blockers:
-closed angle glaucoma, head injuries, severe anemia DON’T TAKE IF YOU HAVE IT! OR SILDENAFIL!!!
Prototype Summary: Nitroglycerin (Nitro-bid)
*Isordil is for chronic angina, taken before chest pain begins in situations where angina is precipitated. *CAUTIONS (asthma, copd, dm, pvd, thyrotoxicosis) ARE DUE TO BB REMOVING THE BODY’S ABILITY TO RESPOND TO ACHIEVE HOMEOSTASIS GI Drugs
*antibacterial drugs are used to eradicate H.pylori ex) Amoxicillin, metronidazole, tinidazole, tetracycline, bismuth
Antacid (Gastric Acid Neutralizers)
Pharmacodynamics
– buffer HCL acid, raise pH, decrease injury to mucosal
Lining
-Too much antacids can lead to acid rebound; this is when the acid levels are are lowered and the stomach produces more gastrin and acid in response; basically just overcomes the effect of antacids
Proton-Pump Inhibitor: block final step of acid production, reduce acid secretion by irreversibly inhibiting the enzyme that produces gastric acid
-increase the risk for pneumonia
Prostaglandins: Synthetic PGE, reduce bicarbonate and mucus production, decrease acid secretions
*Misoprostol (Cytotec) and pregnancy
Pharmacotherapeutics
– prevention of NSAID, Aspirin induced ulcers
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