APHON Chemo Certification Exam | Verified with 100% Correct Answers How many people ages 0-21 are diagnosed with cancer each year? 15,000 - 16,000 What are the top 2 pediatric oncology diagnoses + the % 1. Leukemia -
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APHON Chemo Certification Exam | Verified with 100% Correct Answers How many people ages 0-21 are diagnosed with cancer each year? 15,000 - 16,000 What are the top 2 pediatric oncology diagnoses + the % 1. Leukemia - 29% 2. Brain / CNS - 26% What is the 5 yr survival rate for all peds onc diagnoses? For ALL? For AML? All Dx: > 80% ALL: 90% AML: 65% Natural cell death Apoptosis Cell death from an insult that leads to rupture of the cell membrane and spilling of cell contents Necrosis Regulates normal cell growth and repair Proto-oncogenes Blood cell production Hematopoiesis Period of time when the pt's WBCs are the lowest, from day 7-10 Nadir What time is when a pt is at the greatest risk for infection During Nadir Goal of chemo Stop cell cycle/growth from occurring and coming back Why are multiple chemo agents used? Resistance to a single chemo agent can occur Chemo cells OUT of bone marrow and in the peripheral system Blasts Chemotherapy affects 4 things 1. Malignant cells 2. Epidermal 3. Bone Marrow 4. Epithelial lining S/S of Childhood Cancer fever, HA, n/v, fatigue, pain, petechiae, pallor, changes in gait, pancytopenia, lymphadenopathy, night sweats, hematuria, anorexia, abdominal or extremity mass What 4 things can tumor markers monitor 1. tumor cell origin 2. tumor cell activity 3. therapy response 4. recurrent disease A feature or byproduct of tumor cells that is an indication of tumor cells and its response to therapy Tumor markers Staging of tumors: TNM system T: Tumor size N: lymph Node involvement M: distant Metastases The study of the effect of a drug on the body Pharmacodynamics The movement of a drug in the body and studies how the body affects the administered drug Pharmacokinetics The 4 actions of pharmacokinetics 1. absorption 2. distribution 3. metabolism 4. excretion Term often used to describe the rate of drug excretion Clearance
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