Health Care > STUDY GUIDE > PHSYC 643-Psychopharmacology Study Guide.Module 5(Depression) latest Update 2020 (All)

PHSYC 643-Psychopharmacology Study Guide.Module 5(Depression) latest Update 2020

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Study Guide Module 5: Depression Familiarize yourself with theories of bipolar spectrum disorder and their criticism (Article: Bipolar Spectrum: A Critical Perspective) with consideration of the follo... wing: 1. Patient presentation rarely fits neatly into unipolar depression, bipolar I and bipolar II diagnostic criteria. 2. Treatment decisions can be guided by the bipolar spectrum classification. What are the 3 neurotransmitters most implicated in mood disorders? Serotonin, Dopamine, Norepinephrine Describe the synthesis of norepinephrine. Tyrosine Hydroxylase convert amino acid Tyrosine into DOPA, DOPA decarboxylase convert DOPA to DA, Dopamine b hydroxylase converts DA into NE How is norepinephrine metabolized? Monoamine oxidase (MAO) A or B, Catechol-o-methyl-transferase (COMT) What is the significance of presynaptic alpha-2 receptors? Presynaptic alpha 2 receptors are located in both the axon terminal and soma. Only a2 receptors can act as presynaptic autoreceptors, presynaptic alpha 2 receptors regulate norepinephrine release Describe how norepinephrine regulates serotonin. NE regulates 5HT neuros via alpha 1 and alpha 2 receptors, a1 accelerate and a2 brake Compare the monoamine hypothesis of depression to the monoamine receptor hypothesis and the proposed validity of each. (This information is also covered in Chapter 7.) [Show More]

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