Chemistry > STUDY GUIDE > The University of Sydney COSC MISC CSB421 Lecture Review 2019 (All)

The University of Sydney COSC MISC CSB421 Lecture Review 2019

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WK Video/lecture topics Notes/LO’s/Review Questions 1 Part 1: Intro to CSB421 Part 2: Drugs and drug targets Part 3: Chemical bonding (how molecules get close) Part 4: Organic molecules Part ... 5: Hydrophilic vs lipophilic The important types of intermolecular attractions in medicinal chemistry: Hydrogen bonding Ionic bonding Dipole forces (important in inter molecule bonding) Van der waals forces Notes: Strong and weak partner (X---H) create a polar molecule/group  Define PK/PD  Define drugs and drug targets  How do drugs interact with targets? Other objectives  Know what is expected from the student and the lecturer of CSB421.  Know what the assessment items are.  Recognise that learning requires effort. (The curve of forgetting) LO 1. Recognise the difference between pharmacokinetics and pharmacodynamics 2. Define drug and drug targets and describe how they differ 3. Recognise types of intermolecular attractions and their relative strengths 4. What is hydrophilic/lipophilic, why is this important? 5. Identify hydrophilic and lipophilic functional groups 2 Part 1: Acids and bases Part 2: Ionisation and pKa Notes: Zwitter ions COOH = COO- + H NH4+ = NH3 + H+ HA = Acid (proton donor) A- = Base (proton acceptor) pH  measure of the amount of H+ pKa  measure of the amount of ionisation Study questions 1) How do you know when is a drug an acid or a base? 2) LO  Recognise ionisable functional groups  Identify hydrophilic and lipophilic functional groups  Recognise how ionisation, and functional groups influence solubility 3 Part 1: Stereochemistry Part 2: Drug names and stereochemistry Part 3: Protein structure Part 4: Enzymes (as drug targets) Remember: Study questions 1) How do you know how many stereoisomers a molecule can have How do you define a chiral carbon? [Show More]

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