NR 601 Final Study Guide
Week 5- Glucose Metabolism Disorders/Obesity
Dunphy
Chapter 58: Diabetes Mellitus p.909-938
Kennedy
Chapter 14: Endocrine, Metabolic, and Nutritional Disorders p.369-376
o Obesity p.392
...
NR 601 Final Study Guide
Week 5- Glucose Metabolism Disorders/Obesity
Dunphy
Chapter 58: Diabetes Mellitus p.909-938
Kennedy
Chapter 14: Endocrine, Metabolic, and Nutritional Disorders p.369-376
o Obesity p.392-396
Glucose Metabolism Disorders
Types of diabetes (prediabetes, type 1, and type 2)
Prediabetes: fasting glucose consistently elevated above the normal range but less than 100-125. Impaired
glucose tolerance (IGT) state of hyperglycemia where 2 hr post glucose load glycemic level is 140-199
Type 1: severe insulin deficiency resulting in reduction or absence of functioning beta cells in the pancreatic
islets of Langerhans. This leads to hyperglycemia due to altered metabolism of lipids, carbs, and proteins.
Initial s/s of hyperglycemia.
Subjective findings- polyuria, polydipsia, nocturnal enuresis and polyphagia with paradoxical weight
loss, visual changes and fatigue.
Objective-dehydration (poor skin turgor and dry mucous), wt loss despite normal/increase appetite,
reduction in muscle mass. DKA (fatigue, cramping, abnormal breathing, halitosis (rotten fruit + nail
polish smell)
o Long-stand DM:
retinopathy (1. dilation of retinal venules and retinal capillary microaneurysms. 2.
Increased vascular permeability. 3. Retinal ischemia due to vascular occlusion. 4.
Angiogenesis – proliferation of new retinal surface blood vessels. 5. Retinal hemorrhage
with fibrovascular proliferation and contraction, which may lead to retinal detachment
All these findings should be referred to an ophthalmologist.
Skin complications: chronic pyogenic infections or necrobiosis lipoidica diabeticorum
(plaques with shiny yellow surface on anterior surfaces of legs or dorsal aspects of
ankles)
Paresthesia to distal extremities (foot ulcers, burns on hands from cooking)
Gaze deviations in affected eyes from cranial nerve palsies
Type 2: Type 2 DM is characterized by the abnormal secretion of insulin, resistance to the action of insulin in
the target tissues, and/or an inadequate response at the level of the insulin receptor. A patient may,
however, present with pruritus, fatigue, neuropathic complaints such as numbness and tingling, or
blurred vision.
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