AQA// GCSE BIOLOGY Foundation Tier Paper 1F

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Materials For this paper you must have: • a ruler • a scientific calculator. Instructions • Use black ink or black ball-point pen. • Pencil should only be used for drawing. • Fill in ... the boxes at the top of this page. • Answer all questions in the spaces provided. • If you need extra space for your answer(s), use the lined pages at the end of this book. Write the question number against your answer(s). • Do all rough work in this book. Cross through any work you do not want to be marked. • In all calculations, show clearly how you work out your answer. Information • The maximum mark for this paper is 100. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature I declare this is my own work. GCSE BIOLOGY Foundation Tier Paper 1F F 2 *02* IB/M/Jun22/8461/1F Do not write outside the Answer all questions in the spaces provided. box 0 1 HIV (Human Immunodeficiency Virus) is a pathogen. 0 1 . 1 How is HIV spread from one person to another person? [1 mark] Tick () one box. Coughing Sexual intercourse Touching door handles Table 1 shows information about new cases of HIV diagnosed in the UK. Table 1 Year Number of new HIV cases 2010 2642 2014 2767 2018 1530 0 1 . 2 Describe what happened to the number of new cases of HIV from 2010 to 2018. [2 marks] 3 *03* Turn over ► IB/M/Jun22/8461/1F Do not write outside the box 0 1 . 3 What could cause a decrease in the number of new HIV cases in the future? [1 mark] Tick () one box. A higher population of people in the UK A lower number of trained HIV nurses Better education on how to prevent the spread of HIV 0 1 . 4 Scientists have been working to produce a vaccine for HIV for many years. How could a vaccine work to prevent a person being infected with HIV? Write the stages A, B, C, D and E in the correct order. [3 marks] The first stage has been completed for you. A Antibodies attach to the inactive virus. B Antibodies destroy the inactive virus. C An inactive form of the virus is injected into the body. D If the active virus enters the body, antibodies are produced quickly. E White blood cells produce antibodies to the inactive virus. Question 1 continues on the next page 4 *04* IB/M/Jun22/8461/1F Do not write outside the box 0 1 . 5 When scientists produce a vaccine for a disease the vaccine is tested on live animals. What is the next stage in testing the vaccine? [1 mark] Tick () one box. Testing on cells in a laboratory Testing on healthy volunteers Testing on the whole human population 0 1 . 6 A vaccine for HIV is important because it is difficult to develop safe drugs to destroy viruses. Why is it difficult to develop safe drugs to destroy viruses? [1 mark] Tick () one box. Drugs that destroy viruses also damage body tissues. There are too many viruses for the drugs to destroy. Viruses are too big for the drugs to destroy. 5 *05* Turn over ► IB/M/Jun22/8461/1F Do not write outside the box 0 1 . 7 Some drugs originated from plants. Draw one line from each drug to the plant the drug originated from. [2 marks] Drug Plant the drug originated from Aspirin Digitalis Foxglove Rose Tobacco Willow Turn over for the next question 11 6 *06* IB/M/Jun22/8461/1F Do not write outside the box 0 2 Figure 1 shows animal cells. Some of the cells are dividing by mitosis for growth and repair. Figure 1 0 2 . 1 What fraction of the cells in Figure 1 is dividing by mitosis? [1 mark] Tick () one box. 1 8 1 4 1 2 3 4 7 *07* Turn over ► IB/M/Jun22/8461/1F Do not write outside the box 0 2 . 2 The cells which are not dividing in Figure 1 each contain 10 chromosomes. One of these cells divides by mitosis to produce two new cells. How many chromosomes will each new cell contain after mitosis? [1 mark] Tick () one box. 5 10 15 20 0 2 . 3 Cells divide in a series of stages called the cell cycle. Complete the sentences. Choose answers from the box. [3 marks] contracts divides grows reacts relaxes replicates Before mitosis occurs, the cell . The genetic material in the cell doubles when the DNA . After the chromosomes have been pulled to each end of the cell, the cytoplasm . Question 2 continues on the next page 8 *08* IB/M/Jun22/8461/1F Do not write outside the box Figure 2 shows the time taken to complete different stages of the cell cycle. Figure 2 0 2 . 4 Which stage of the cell cycle takes the most time? [1 mark] Tick () one box. A B C 0 2 . 5 What percentage of time in the cell cycle is stage A? [1 mark] Tick () one box. 5% 10% 15% 25% 9 *09* Turn over ► IB/M/Jun22/8461/1F Do not write outside the box Stem cells divide by mitosis. Scientists can use stem cells from an embryo to create heart cells in a laboratory. 0 2 . 6 Which organ system contains heart cells? [1 mark] Tick () one box. Circulatory system Digestive system Nervous system Respiratory system 0 2 . 7 Name one medical condition that could be treated using heart cells created from an embryo. [1 mark] 0 2 . 8 Give one reason why a patient may not [Show More]

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