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University of Pennsylvania - BIOL 204BIOL 204 (2017) Problem Set 4 + Key

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Biology  204 Spring  2017/REA 1 Problem  Set  4:  Transport  across  membranes Questions: Most of these problems are based on real-world experiments (or fabricated exp... eriments based on real-world data), and in several cases experiments of the type that gave rise to fundamental insights into the mechanistic basis of transport across biological membranes. Question 1 concerns a rare congenital disorder that may be more common than is generally appreciated. Question 2 addresses a few of the common issues that arise when examining primary transport and of the sidedness of the biochemistry at play. Questions 3 and 4 bring to light a fundamental difficulty (one based on bitter experience) that is often encountered when attempting to assay the activities of reconstituted primary ion pumps for the first time. Question 5 is a fairly standard textbooktype question. Questions 6 and 7 introduce you to the types of experiments from which specific transport systems were first discovered. [Show More]

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