Most common chronic respiratory disorder among all age groups
Asthma
Atophy
exaggerated IgE mediated immune response; all atophic disorders are type I hypersensitivity
disorders
Type I hypersensitivity reaction
Imm
...
Most common chronic respiratory disorder among all age groups
Asthma
Atophy
exaggerated IgE mediated immune response; all atophic disorders are type I hypersensitivity
disorders
Type I hypersensitivity reaction
Immediate hypersensitivity
IgE-mediated
Antigen binds to IgE that is bound to tissue mast cells and blood basophils, triggering release of
preformed mediators (histamine, proteases, chemotactic factors) and synthesis of other mediators
(prostaglandins, leukotrienes, platelet-activating factor, cytokines)
-causes vasodilation, increased cap. permeability, mucus hypersecretion
**atopic disorders (allergic asthma, rhinitis, conjunctivitis), anaphylaxis, some cases of
angioedema, urticarial, and latex and some food allergies
**Develop <1h after exposure to antigen
Allergic triad of symptoms
allergies, eczema, and asthma
Samter's Triad
Nasal polyps, asthma, and ASA allergy
Most common symptom of asthma
wheezing
Common only symptom of asthma?
Cough
-can often delay dx of asthma
AKA cough variant asthma
Best way to confirm asthma dx?
bronchial provocation
Intermittent asthma
sx
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Last updated: 3 years ago
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