1. What are the 6 characteristics of a goal drug?
1.) Produces specific desired effect
2.) Is administered by the most desired route (generally orally) at minimal dosage and
dosing frequency
3.) Have optimal onset a
...
1. What are the 6 characteristics of a goal drug?
1.) Produces specific desired effect
2.) Is administered by the most desired route (generally orally) at minimal dosage and
dosing frequency
3.) Have optimal onset and duration of activity, and exhibit no side effects
4.) Is eliminated from the body efficiently, completely, and without residual effect.
5.) Is easily produced at low cost and pharmaceutically elegant
6.) Is physically and chemically stable in various conditions of use and storage.
Although not completely attainable in practice, these qualities and features are sought
in drug and dosage form design.
2. What is a lead compound?
A lead compound is a prototype chemical compound that has a fundamental desired
biologic or pharmacologic activity. Although active, the lead compound may not possess all of
the features desired, such as potency, absorbability, solubility, low toxicity, and so forth.
3. What is a prodrug?
Prodrug is a term used to describe a compound that requires metabolic biotransformation
after administration to produce the desired pharmacologically active compound. The conversion
of an inactive prodrug to an active compound occurs primarily through enzymatic biochemical
cleavage.
4. Name the 4 areas that preformulation studies focus on:
Each drug substance has intrinsic chemical and physical characteristics that must be
considered before the development of a pharmaceutical formulation. Among these are the drug's:
solubility, partition coefficient, dissolution rate, physical form, and stability.
5. Define dissolution rate?
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