BioBeyond Unit 6 : Protein and Protein Technology

BioBeyond Unit 6 : Protein and Protein Technology what is the best place to start your analysis to see if they are carriers for the genetic disorder cystic fibrosis ? - ✔✔A DNA sample to study their genomes and their ...

BioBeyond Unit 6 : Protein and Protein Technology what is the best place to start your analysis to see if they are carriers for the genetic disorder cystic fibrosis ? - ✔✔A DNA sample to study their genomes and their genome sequence. each protein has a small description; after reading it choose the best category for that protein from the drop-down menu - ✔✔Hexokinase - Enzyme Collagen - Structural Insulin - Signaling Hemoglobin - Transport Myosin - Motor Fibrin Defense at right, mark the boxes next to the steps and products that you think will be affected - ✔✔Step 1 : Product 1 Step 2 Product 2 Step 3 Product 3 Step 4 Product 4 what would happen if the protein was damaged ?select all that apply - ✔✔The mucus channels would stop working Mucus could not pass through the channels A build up of mucus would cover in the airway what health concerns would arise from damage lung tissue ? select all that apply - ✔✔The patient might die The patient might have trouble breathing The patient's cells might not get enough oxygen Match each level of protein structure with its correct description - ✔✔Primary structure ➡️ A sequence of amino acids, bound together in a peptide chain Secondary structure ➡️ Complex structures such as alpha helixes and beta sheets arise Tertiary structure ➡️ A fully formed and folded polypeptide (protein chain) Quaternary structure ➡️ Two or more polypeptides bound together to form a protein What is the main difference between the two proteins ? - ✔✔The shape is different ; one of the active sites is blocked and that protein won't work well Match the following bond types with the appropriate description : - ✔✔Polar covalent ➡️ Electrons are unequally shared between 2 atoms, resulting in a partial change Non-polar covalent ➡️ Electrons are equally shared between two atoms, resulting in no change Iconic ➡️ Electrons are unequally shared between two atoms, resulting in a partial change if an amino acid was changed, how could that impact the protein? Select all that apply - ✔✔ALL OF THE ABOVE using the data at right, if a mutation caused the alanine in the first position to become a glycine, would the polarity of the amino acid in that position change ? - ✔✔No because glycine and alanine have about the same polarity sort the scenario so that the most functional protein is at the top of the list and the least functional protein is at the bottom - ✔✔The patient's gene is an exact match to a normal gene The patient's gene has many mutations with no change in the protein's polarity The patient's gene has many mutations abs the protein is less polar than normal The patient's gene is 60% the length if a normal gene rank the following mutations by the severity of their consequences to the organism. - ✔✔1 : Nonsense mutation 2: Missense Mutation 3 : silent mutation when we compare the DNA from the Johnsons to each other or to a standard sequence, would you expect to see some variation? - ✔✔Yes, i would expect variation between two organisms since we do expect differences, or mutations, in the DNA, which type of mutation is the least harmful? - ✔✔Silent if we analyze the DNA and find mutations that causes the peptide sequence to change, what type of mutation is present? - ✔✔missense If we compare the DNA and we saw that there was a change in the length of the DNA sequence, what type of mutation are we observing? - ✔✔nonsense What can you conclude about Mr. Johnson's CFTR gene ? - ✔✔it is different from the healthy gene, but not in a dangerous way Looking at Mrs. Johnson's CFTR gene vs the healthy copy , what can you conclude - ✔✔It is different from the healthy gene, but not in a dangerous way do you remember which human body system fights infections? - ✔✔immune Which disorder should we test for, since baby Johnson is having issues with her immune system? - ✔✔Adenosine Deaminase Deficiency Looking on the image in the right, what do you see - ✔✔has significant differences describe any differences you see between the two DNA strands - ✔✔this DNA sequence has a nonsense mutation, resulting in it being much shorter than expected. It's highly unlikely this protein would function at all. imagine that the protein folded in a way that block the site; what was the consequences be? - ✔✔The protein would not work and there would be other consequences would the protein be able to work properly - ✔✔no it will not work at all explain reasoning - ✔✔since the protein didn't from, it no longer has the active site, therefore, this protein will not function at all Why would Disrupting new DNA constructions be a concern for human health? - ✔✔DNA contains your genetic blueprint if DNA cannot be copied as quickly as normal, what would the impact be on the production of new cells? - ✔✔The impacts would be worse for some cells than others, since not all cells contain DNA and not all cells are made at the same time if we can fix damaged DNA, which of the following afflictions might we be able to treat? Select all that apply - ✔✔sickle cell anemia type 1 diabetes cystic fibrosis adenosine deaminase deficiency if we could change DNA sequences, we could change ______ - ✔✔ALL OF THE ABOVE See if you can match each organism to what percent of its DNA is shit with humans. - ✔✔banana ➡️ 50% dog ➡️ 75% chimpanzee ➡️ 99% mountain gorilla ➡️ 96% which treatment would you recommend for baby Johnson? - ✔✔CRISPR/Cas-9 gene editing increased safety increased likelihood of success more ethically acceptable