ASCP MB Exam Questions and Answers 100% Pass

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ASCP MB Exam Questions and Answers 100% Pass Acute Promylocity Leukemia (APL) ✔✔t(15:17) PML / RARa genes Chronic Myelogenous Leukemia (CML) ✔✔t(9:22) a.k.a. Philadelphia chromosome ABL1 / BCR genes Burkitt's non-Hodkin's Lymphoma ✔✔t(8:14) dysregulation of c-myc gene breakpoints on ch.8 spread over 190kbp region 5' to 3' Follicular non-Hodkin's Lymphoma ✔✔t(14:18) IgH / BCL2 genes Mantle Cell Lymphoma (MCL) ✔✔t(11:14) CCND1 / IgH genes overexpression of cyclin D1 (cell cycle gene) MALT Lymphoma (a.k.a. Marginal Zone) ✔✔t(11:18) API2 / MLT genes "mucosa-associated lymphoid tissue" Haploid Genome ✔✔3.3 billion bp Carbamazepine Resistance ✔✔HLA B1502 Factor V Leiden ✔✔c.1691G>A / p.R506Q causes Thrombophilia Cystic Fibrosis mutation ✔✔delta F508, 3bp deletion HERceptin Therapy ✔✔HER2+/neu Overexpression of HER2 receptors causing cancer cells to grow Vancomycin Resistance (Enterococcus) ✔✔van A MRSA (resistant staph) ✔✔mec A Mycobacterium tuberculosis ✔✔katG, inhA Most cancerous HPV ✔✔Strain 16 - 70% of all cases Graft vs Host Disease ✔✔Linked w CMV replication (Cytomegalovirus) Viral load change HCV ✔✔.3log10 Viral load change HIV ✔✔.5log10 HCV Genotypes ✔✔Genotype 1 - 75% Genotype 2 and 3 - 20-25% DNA A260 ✔✔50ug/ml/1OD (answer on ascp is .560) What inhibits topoisomerase? ✔✔Irinotecan KCL in PCR ✔✔Helps short DNA fragments range 100bp to 1000bp at 70mM to 100mM FISH ✔✔Prade-Willi # of amplification products ✔✔(1+E)^n RNA POL I ✔✔rRNA RNA POL II ✔✔mRNA, snRNA RNA POL III ✔✔tRNA RNA POL IV ✔✔mitochondrial RNA Histones ✔✔Ionic; (+) charged Arginine and Lysine Cutaneous T-Cell Lymphoma (CTCL) ✔✔Vorinostat - 1st FDA approved drug (also treats Sezary syndrome) HCV most virulent ✔✔1b HCV most conserved ✔✔5' UTR HLA want to PCR HLA-D ✔✔beta exon 2 Invader Assay enzyme ✔✔Cleavase Melting temp question ✔✔48 Why primer dimers ✔✔3' complementarity A260/A280 ✔✔Protein < 1.8-2.0 < RNA Telomerase ✔✔Reverse transcriptase Fragile X Syndrome ✔✔>200 CGG repeats 5'UTR of chr.X Huntington's Disease ✔✔>40 CAG repeats ex1 chr.4 Common oncogene ✔✔K-Ras Protein involved in cell division Common tumor suppressor ✔✔TP53 Leading DNA Pol ✔✔Delta Lagging DNA Pol ✔✔Alpha Repair DNA Pol ✔✔Epsilon Mitochondrial DNA Pol ✔✔Gamma Taq polymerase ✔✔5'-3' exonuclease bDNA enzyme ✔✔alakaline phosphatase Separates DNA ✔✔helicase Unwinds DNA ✔✔topoisomerase Nephrotic kidney (Post-transplant virus) ✔✔BK virus Kidney Failure ✔✔HIV EBV - Epstein-Barr virus aka "Herpes" ✔✔Post-transplant Lymphoproliferative patients Early diagnosis of EBV ✔✔RT-qPCR homologous chismata formation ✔✔prophase I Cell cycle entry ✔✔G1 to S Hallmark feature of TNR disorders ✔✔Anticipation [HLA Typing] Advantage of molecular testing over seriological phenotyping? ✔✔1. Viable cells are NOT needed 2. Null alleles can be detected

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