final ICRC, Questions and answers. 100% accurate, rated A+

final ICRC, Questions and answers. 100% accurate, rated A+ CAGE - ✔✔• The briefest and most widely used. • Only four questions asked directly to the person. • If someone answers yes to one of the questions then ther ...

final ICRC, Questions and answers. 100% accurate, rated A+ CAGE - ✔✔• The briefest and most widely used. • Only four questions asked directly to the person. • If someone answers yes to one of the questions then there is an indicator that their might be a problem that needs to be further investigated. • If they answer yes to two or more they are sent for further testing. • Advantages-yes or no questions • Disadvantages-not asking about time frame, self report, not in depth about environment, not in depth MAST - ✔✔• Widely used • Good reliability and validity • Original had 25 self administered questions the one now has only 22. • Advantages-it could be a reality check to someone taking it, not very time consuming, simple yes and no • Disadvantage-it doesn't ask you to explain, doesn't ask time frame AUDIT - ✔✔• Ten items 1-3 frequency and quantity 4-6 alcohol dependence 7-10 how harmful alcohol use. • Advantages-you can use it in an interview, it's not that long, it's more specific • Disadvantage-not specific enough, doesn't add in the times when drinking is more acceptable like vacation etc., not valid • Can be self report questionnaire or an interview DAST - ✔✔Screen drugs other than alcohol POSIT - ✔✔139 items on it Used for substance use problems and social, behavioral, and learning problems Disadvantages-too long, repetitious, lack of consistency Advantages-more detailed SASSI - ✔✔• Doesn't directly question about alcohol/drug use (not like the previous ones) • Around 50 questions • Asks questions about alcohol/drug use on one side and don't on the other • Looking for defensiveness, looking at others, personal affect • Disadvantages-could be hard to profile DSM Axises - ✔✔o Axis I-Clinical syndromes • Alcohol abuse, cannabis dependency o Axis II-Personality disorders/mental retardation • Not used very often in alcohol or chemical use o Axis III-Medical Conditions • Psuerosis of the liver o Axis IV-Psychosocial/environmental stressors • Losing kids because of substance abuse, lacks good social support system o Axis V-Global assessment of functioning • 0-100 how the person is functioning overall Narcotics possible effects - ✔✔Euphoria, drowsiness, respiratory depression, constricted pupils, nausea Narcotics effects of OD - ✔✔Slow/shallow breathing, clammy skin, convulsions, coma, and possible death Narcotics withdrawal syndrome - ✔✔Water eyes, runny nose, yawning, loss of appetite, irritability, tremors, panic, cramps, nausea, chills, sweating. Narcotics - ✔✔Heroin, Morphine, Hydrocodone, Hydro-morphone, Oxycodone, Codeine Depressants - ✔✔Hydroxybutyric Acid, gamma, Benzodiazepines etc. Depressant effects - ✔✔slurred speech, disorientation, drunken behavior without odor of alc., imparired membory of events, interacts with alc. Depressant overdose - ✔✔shallow respiration, clammy skin, dilated pupils, weak and rapid pulse, coma, and possible death. Depressant withdrawal - ✔✔Anxiety, insomnia, tremors, delirium, convulsions, possible death. Stimulants - ✔✔Cocaine half life=one hour, Amphetamine=6-12 hours, Methylphenidate=2 hours Stimulant effects - ✔✔Increased alertness, excitation, euphoria, increased pulse rate, increased blood pressure, insomnia, and loss of appetite, dialated pupils. Stimulant OD - ✔✔Agitation, increased body temperature, hallucinations, convulsions, and possible death Stimulant withdrawal - ✔✔Apathy, long periods of sleep, irritability, depression (possible with suicidal potential), and disorientation, increased appetite, anhedonia (absence of pleasure) and craving. Hallucinogens - ✔✔MDMA and Analogs, LSD, Phencyclidine, Hallucinogen signs and symptoms - ✔✔Increased reflexes, tremors, weakness, flushing and chills, seizures, inappropriate mood, elation, hallucinations, bizarre behafvior, diorientation, confusion, delusions, and impaired judgement. Hallucinogen OD - ✔✔Increased body temp, electorlyte imbalance, cardiac arrest, unable to direct movement, feel pain, or remember. Hallucinogen withdrawal - ✔✔Muscle aches, drowsiness, depression, acne, and drug seeking behavior. Cannabis effects - ✔✔Euphoria, relaxed inhibitions, increased appetitie, disorientation, Cannabis problems - ✔✔impairment of ability to learn. Medical effects wth prolonged use include respiratory problems, possible impaired immune function and possible reproductive problems includinglow birth weight infants. Cannabis withdrawal - ✔✔Rare. Appear limited to some heavy users. Possible irritability, restlessness, craving, loss of appetite, nausea, diarrhea, muscle twitching, overt aggression and depression. Anabolic Steroids effects - ✔✔Virilization, edema, testicular atrophy, gyneco-mastia, acne aggressive behavior Anabolic Steroids withdrawal - ✔✔Possible depression Inhalants effects - ✔✔flushing, hypotension, headache, cardiac depressants leading to "sudden sniffing death. Inhalants signs and symptoms - ✔✔possible asphyxiation and frostbite of nose, lips, or larynx if inhaled from a tank, loss of motor control, nausea, ataxia, muscle weakness, dysarthia, nystagmus, diminished reflexes. Inhalants withdrawal - ✔✔Agitation -pyschological but no known physical symptoms Alcohol common problems - ✔✔Tolorance, Dependence, Depression, neurologic deficits, hypertension, liver and heart disease. Alcohol OD - ✔✔Vomiting, respiratory depression, loss of consciousness, possible death. Alcohol Withdrawal - ✔✔Trembling, autonomic hyperactivity, Anxiety, insomnia, vitamin deficiency, confusion, hallucination, and convulsions. Alcohol acute effects - ✔✔low doses: eupohoria, mild stimulation, relaxation, and lowered inhibitions. high doses: drowsiness, slurred speech, nausea, emotional volatility, loss of coordination, visual dostortions, impaired memory, sexual dysfunctions, loss of consciousness/increased risk or injuries, violence, fetal damage. Sedative Hypnotics desired effects - ✔✔Similar to alcohol. Reduction of anxity; possible elation, secondary to decrease alertness and judgment. Sedative Hypnotics acute effects - ✔✔Sedation, impaired judgement, impaired operation of vehicles, respiratory and cardiac depression with overdose (much less likely with benzoidiazepines alone). Sedative Hypnotics interaction with alcohol - ✔✔Potentiation of effects, especially respiratory depression, Some degree of cross tolorance. Sedative Hypnotics common problems - ✔✔Tolerance, dependence, addiction, elderly falls, respiratory dpression Sedative Hypnotics withdrawal - ✔✔Similar to alcoho, but may have slower onset. Severity and time of onset vary wtih half life of drug. Mild: anxiety, restlessness, nausea, vomiting, insomnia, hpertention, tachycardia, agitation, tremors, sensory, hypersensitivity, dizziness, confusion, fatigue. Severe: Autonomic hyperactivity, vital sign instability, elevated temp, delusions, hallucinations, mania, delirium, catatonia, seizures, tremulousness, altered perceptions, w/d seizures possibly leading to death. Sedative Hypnotics Medical uses - ✔✔Sleep, anxiety, muscle relaxation, alcohol, and sedative/hypnotic w/d, control of seizures includes Benzodiazepines, barbiturates, and others. Sedative Hypnotics physica/mental exam - ✔✔Slurred speech, ataxia, stupor, coma, and for nonbenzo's respiratory depression. confulsion, impaired judgement, delirium. Cocaine action - ✔✔affects dopamine, norepinephrine, and serotonin levels. Blocks re-uptake of dopamine, prolonging dopamine effects. Depleats it with prolonged use. Toxic effects on cardiac, respiratory, and cns. Amphetamines and Methylphenidate action (stimulant) - ✔✔Direct neuron release of dopamine and norepinepherine and blockade of catecholamine re-uptake produce euphoric effects. Various toxic effets on the sympathetic nervous system. Stimulant physical and mental status - ✔✔pupils dialated, dry mouth, cardiac arrhythmias, twitching, tremors, convulsions, stroke, coma, confusion, disinhibited behaivor, parnaoid thoughts, hallucinations, hyper vigilance, elevation and or depression, suciadal behavior, impaired judgement. Opiates Action - ✔✔Bind to opiate receptors in the cns where they block normally occuring opiate-like substances. Opiate acute effects - ✔✔sedation, decreased judgement, decreased ability to operate vehicles, posssible respiratory depression if oding. Opiate W/D - ✔✔Drug craving, dysphoria, anxiety, yawning, perpiration, sleep difficulties, fever, chills, gooseflesh, abdominal cramps, nausea, diarrhea, muscle cramps, bone pain tears. Opiate problems - ✔✔Rapid acquired tolerance, dependence, respiratory dpression, cellulitis, sepsis, endocarditis, @ risk for HIV, and legal problems. Opiate physical/mental exam - ✔✔Pupil constricted, relexes absent or diminished, pulmonary edema, convulsions. Euphoria, sedation, possible normal mood, possible stupor. Opiate users - ✔✔rate of relapse goes down by 60% 6 months to 1 year after stopping methodone/suboxonel maintenance. Medical Marijuana - ✔✔FDA has not cleared it. The ill affects of smoking far out weigh the medical affects. THC - ✔✔Fat soluable-stored in fat-time released, hard to recognize withdrawal. Cannabis signs and symptoms - ✔✔Red eyes, mild dilation of pupils, mild tremor, decreased coordination, decreased strength, less ability to perform complex motor tasks and dry mouth, feelings of depersonalization, anxiety, panic, memory problems, alterationin mood disorganization, hallucinations, paranoid thoughts. Hallucination LSD acute effects - ✔✔panic attacks, increased b/p, heart palpitiations, tremors, nausea, muscle weakness, increased body temp, ataxia, accidental dealth (believing one can fly). Hallucination MDMA acute effects - ✔✔Nausea, jaw and teeth clenching, muscle tension, blurred vision, panice attacks, confusion, depression, anxiety, paranoid psychosis, hyperthermia, and cardiac arrest. Phencyclidine (PCP) Action - ✔✔Behvior effects believed to be meediated through the N-Methyl-DAspartate (ND) excitatory amino acid receptor-channel complex in the brain. PCP acute effects - ✔✔visual illusions, hallucinations, and distroted perceptions, feelings of stregth, power, and invulnerability, depresonalization, distorted body image. PCP common problems - ✔✔Psychotic reactions, bizarre behavior, ooutbursts of hostililty and violence, feelings of anxiety, doom or impending death, gross impairment of coordination, nystagmus, hypersalivation, vomiting, fever. With longterm use: Persistent cognitive and memory problems speech difficulties, mood d/o, loss of puposive activities and weight loss. PCP w/d - ✔✔Limited reports of w/d effects. Depression, drug craving, increased appetitie and increased need for sleep PCP signs and symptoms - ✔✔Red eyes, muscle rigidity, increased reflexes, repetitive movements, flushing, salivation, sweating, nausea, vomiting, possible coma, seizures, stroke. Abnormal appearance and behavior, diorientation, inappropriateeffect, memory problems, depression, elation, suicidal or homicidal behavior, and impaired judgement. behavioral view of etiology - ✔✔suggests the influence of both positive and negative reinforcement as causal factors for continued drug use. pleasure pathway in the brain - ✔✔mesolimbic dopamine system GABA transmitters - ✔✔located in the mesolimbic system stimulated by certain drugs Alcohol flush syndrome - ✔✔causes an individual to feel sick after consuming alcohol because of a lack of the enzyme aldehyde dehydrogenase. aldehyde dehydrogenase - ✔✔breaks down acetaldehyde, a by-product of alcohol . The treatment and recovery continuum of care - ✔✔identification, assessment, stabilization, rehabilitation, relapse prevention and substance substitution (if necessary) identification - ✔✔can be through self, court order, a condition of probation or parole, or intervention. screening process helps determine the likelihood of a problem with drugs or alcohol assessment - ✔✔the collection of data from the individual and corroborative sources to determine the extent of the individual's problem and their strengths, weaknesses, and needs. stabilization - ✔✔includes the need for detoxification at an appropriate medical facility if needed. rehabilitation/treatment programs - ✔✔depends upon assessment and diagnosis and can range from providing education, an intensive outpatient program to an inpatient residential program. relapse prevention program - ✔✔a process whereby indentification of individualized triggers and a plan to confront those triggers is developed Stages of family response to drug and alcohol abuse - ✔✔denial, attempts to eliminate the problem, disorganization and chaos, reorganization in spite of the problem, efforts to escape, family reorganization. Dysfunctional family roles - ✔✔family hero, mascot, scapegoat, lost child pancreatitis - ✔✔this occurs when swelling of the pancreatic duct causes a backup of digestive juices causing irritation and swelling of the pancreas. acute fatty liver - ✔✔this occurs when fat deposits build up in the normal liver cells and can develop in anyone who has been drinking heavily even for a short period of time. acoholic hepatitis - ✔✔occurs after a heavy or extended bout of alcohol use and can occur in nonalcohol dependent persons. An inflammation of the liver where metabolism is disrupted, jaundice, yellowing of the skin and whites of the eyes. cirrhosis - ✔✔permanent, widespread destruction of liver cells, which are replaced with nonfunctioning scar tissue. irreversible and fatal if alcohol continues to be used. alcoholic heart muscle disease or AHMD - ✔✔a serious condition in which the heart does not pump the amount of blood needed to meet the demands of the body. Beriberi heart disease - ✔✔a reduction of vitamin B-1 that over time cause a normal heart to fail to keep up with an abnormally high metabolic need of the body. Alcoholic dementia - ✔✔an overall decline of intellect Wernicke's disease - ✔✔associated with Vitamin B1 deficiency and may be corrected nutritionally Korsakoff's psychosis - ✔✔apparently irreversible condition characterized by the individual's inability to learn new information and remember recent events. Wernicke-Korsakoff syndrome - ✔✔combined condition of Wernicke's encephalopathy and Korsakoff's syndrome - symptoms include nystagmus (abnormal eye movement), problems with gait, memory, confabulation, low Bi, low blood pressure, tremor. Often called wet brain. dependence - ✔✔a condition where, after using drugs, an individual finds it difficult or impossible to control use. Dependence usually involves a physical and or psychological need for the drug in order to function normally and it usually involves tolerance and withdrawal. Physical dependence - ✔✔a state of functional adaptation to a drug in which the presence of a foreign chemical becomes normal and necessary, and the absence of the drug would present an abnormal state. Psychological dependence - ✔✔when the individual has a strong desire to continue to use the drug for emotional reasons and is related to the rewarding effects of the drug. There are no physical withdrawal symptoms with the discontinuation of use. Cross-dependence - ✔✔this is evident when a person who is physically dependent on one drug can lessen or prevent withdrawal symptoms by using other drugs from the same or similar classification. Tolerance - ✔✔an altered physiological state that develops after repeated drug use when the body becomes accustomed and adapts to the presence of the drug and functions normally. Evidence of this is when the drug has less of an effect when using the same dose, or when a larger dose must be used to get the desired effect. Pharmacodynamic tolerance - ✔✔when the nerve cells become less sensitive to the effects of the drug over time and repeated use metabolic tolerance - ✔✔when the liver adapts to the presence of a drug over time and may produce more of the enzyme needed to break down the drug. behavioral tolerance - ✔✔when after a period of time and repeated drug use, the users are able to modify their behavior in hopes that others will not notice they are intoxicated reverse tolerance - ✔✔when the individual can become more sensitive to the drug's effects rather than less sensitive. Also known as the kindling effect. half-life - ✔✔the length of time a drug remains in the body and continues to affect the user. effective dose - ✔✔the amount of a drug necessary to get the desired effect in about 50 percent of those who use the drug therapeutic index - ✔✔the dose determined to be safe for use and get the desired effect; determined by dividing the lethal dose by the effective dose potency - ✔✔the amount of a drug necessary to produce the desired effect. drug interaction classifications - ✔✔addititive, synergistic, antagonistic additive effects - ✔✔two or more drugs are used at the same time and the results are equal to the sum of the actions of the drugs used. synergistic interactions - ✔✔when two or more drugs are used at the same time, and the results are greater that the sum of the actions of the drugs used. antagonistic interactions - ✔✔occur when two or more drugs are used at the same time, and the results are less than the sum of the actions of the drugs or the drugs cancel out the effects of each other. Routes of administration - ✔✔how a person takes substances into the body oral administration - ✔✔taken by mouth and swallowed into the stomach. injected - ✔✔using a needle and syringe subcutaneously - ✔✔skin-popping, injecting in the fatty layer just under the external skin. intramuscularly - ✔✔injected into the large muscles intravenously - ✔✔injected directly into a vein inhalation - ✔✔substances can be inhaled into the lungs by smoking or huffing snorting - ✔✔drugs can be inhaled into the nose and absorbed through the mucous membranes. transdermal - ✔✔the drug is absorbed through the skin from a patch. buccal administration - ✔✔the drug is absorbed through the mucous membranes in the mouth. rectal administration - ✔✔Drugs are administered by inserting them into he body through the rectum and are absorbed through the intestinal lining. neorotransmitters - ✔✔GABA, norepinephrine, dopamine, serotonin, acetylcholine. GABA - ✔✔relates to inhibitory factors and slows communication. Norepinephrine - ✔✔associated with arousal reactions and moods. Dopamine - ✔✔associated with feeling of pleasure. Serotonin - ✔✔associated with feelings of anxiety, depression and aggressiveness. Acetylcholine - ✔✔associated with arousal reactions or inhibitory factors. Pleasure/reward center of the brain - ✔✔made up of the ventral tegmental area (VTA), nucleus accumbens and other structures of the brain. Fat-soluble drugs - ✔✔These store in the fatty areas of the body and can have longer lasting traces in the body that water-soluble drugs do not. Abuse potential - ✔✔generally related to the drug's speed of action and how long the effects last. Contolled Substance Act - ✔✔Law which places drugs in 1 of 5 schedule categories, depending on their abuse potential, potential for dependence/addiction, and currently accepted medical use. Schedule I - ✔✔Any drug included here has a high level of abuse/dependence. Also, there is no accepted medical use. Include are heroin, LSD and marijuana. Schedule II - ✔✔Drugs in this category are essentially similar to Schedule I, but with an accepted medical use. There are restrictions on manufacture and distribution via production quotas and import/export controls. Non-refillable meds. Include methadone, morphine, methamphetamine and cocaine. Schedule III - ✔✔Drugs in this category are considered to be at moderate or low risk for physical dependence, and with current reasons for medical use. Includes anabolic steroids, most barbituates and ketamine. Schedule IV - ✔✔Drugs in this category are considered to be at low risk for physical dependence but moderate risk for psychological dependence and have a currently accepted medical use. Includes Xanax, Barbital and chloral hydrate. Schedule V - ✔✔Drugs in this category are considered to be at low risk for either physical dependence or psychological dependence, and with current indications for medical use. Includes medical mixtures using small amounts of opium or codeine. Depressants/Sedative-hypnotics - ✔✔These drugs are central nervous system depressants. Include but are not limited to: alcohol, benzodiazepines and barbituates. In general these drugs bind to GABA receptors resulting in sedation. Stimulants - ✔✔Drugs in this class increase cental nervous system activity. Includes cocaine, amphetamines, methamphetamines, and methylphenidate. Hallucinogens/Dissociatives - ✔✔These drugs change sensory perception and have the ability to alter reality and produce hallucination-like effects. Includes naturally occuring and synthetic drugs such as: LSD, mescaline, psylocybin, psilocin, MDMA, PCP and ketamine. Cannabinoids/cannabinols - ✔✔Includes marijuana, hashish and THC Inhalants - ✔✔Chemicals that can be legally purchased and that are normally used for non-recreational purposes. Includes industrial solvents and aerosol sprays and include, but are not limited to: gasoline, kerosene, airplane glue, acetone, lighter fluid, metallic paints, correction flids, amyl, butyl and isobutyl nitrite and nitrous oxide. Anabolic steroids - ✔✔Synthetic illicit drugs that are used to increase muscle mass and improve athletic performance. Include Depo-testosterone, Durabolin, Danocrine, and Halotestin. Some are approved for veterinary medicine and sold illicitly for human use. Stacking - ✔✔combining oral and injectable steroids. Symptoms of Depressant intoxication - ✔✔decreased inhibition, slowed reaction times, memory impairment, possible decrease in respirations, slurred speech, ataxia, Symptoms of Stimulant intoxication - ✔✔increased heart rate, elevated blood pressure and temperature, decreased respiration. dilated pupils, dry mouth, cardiac arrhythmias, twitching tremors, impaired judgment, confusion, disinhibited behavior, paranoid thoughts, hypervigilance, hallucinations, elation. Symptoms of PCP adverse reactions - ✔✔psychotic reactions, bizarre behavior, outbursts of hostility and violence, severe anxiety, doom or impending death. Adverse Ketamine reacation - ✔✔Completed sensory detachment, explained as a near-death experience, paranoia, boredom and possible coma. Symptoms of cannabinoid intoxication - ✔✔slowed reaction time, altered perceptions, panic, anxiety, nausea, dizziness, depersonalization, paranoid thoughts, trouble expressing thoughts. May cause increases in respiration and heart rate and a slight increase in body temperature. Red eyes, mild dilation, mild tremors, decreased coordination, decreased strength, less ability to perform complex motor tasks and dry mouth. Symptoms of Inhalant intoxication - ✔✔reduction of inhibition and euphoria, dizziness, slurred speech, unsteady gait and drowsiness. Nystagmus may be noted, altered consciousness and enhanced sexual pleasure. Nystagmus - ✔✔the constant involuntary movement of the eyes. Ataxia - ✔✔impaired gait Whether we see drug use as a problem depends on all of the following: - ✔✔Reason one takes a drug Quantity consumed and the manner by which one takes the drug When and where the drug is used The age of the individual taking the drug In reference to psychoactive drug use, it is important to recognize that: - ✔✔History and expectations influence how one is affected by a drug. Type I error - ✔✔alpha error - null hypothesis is rejected as false or unproven when it is actually true. The highest rates of illicit drug use are in what age group? - ✔✔18 to 25 Drug use is positively correlated with? - ✔✔rejection of traditional cultural systems No Wrong Door - ✔✔Treatment is available at every point of someone trying to get help in any stage of substance abuse. The first of the pharmacological revolution was associated with the development of? - ✔✔vaccines The age group that is least likely to have used alcohol in the previous 30 days is? - ✔✔12 to 17 Which of the following is an example of behavioral toxicity? - ✔✔driving inattentively after smoking marijuana An experiment in which rats were allowed to self-inject drugs showed that the rats? - ✔✔were more likely to die form cocaine than heroin Which drug is most clearly linked to violent crime? - ✔✔alcohol Alcohol use is associated with? - ✔✔3/5 of all murders 40% of all assaults 1/3 of forcible rape and child molestation 50% committing violent crime The number of people in the US arrested for drug-law violations each year is? - ✔✔1,000,000 About 1/2 of the emergency room episodes and 3/4 of the drug related deaths are associated with? - ✔✔multiple drug episodes All of the following are types of prevention: - ✔✔primary prevention secondary prevention tertiary prevention All of the following are key elements of the social influence model: - ✔✔training refusal skills countering advertising use of teen leaders Type II errors - ✔✔beta error- null hypothesis is not rejected when it is actually false. Often result of too small of sample size. Tertiary prevention programs are those aimed mainly at? - ✔✔people who have been treated for substance abuse or has stopped the substance abuse without assistance Secondary prevention programs are those aimed mainly at? - ✔✔People who have tried the drug in question or a variety of other substances Naltrexone-synthetic opioid antagonist - ✔✔blocks opioids from binding to receptors reduces craving for alcohol was approved by the FDA in 1994 for the treatment of alcoholism Disulfiram: Trade name Antabuse - ✔✔Tablet by mouth once daily - may be crushed. 250mg or 500 mg. Typically begins about 10 to 30 min after alcohol is ingested. May occur for up to 14 days after last dose. Inhibits the enzyme aldehyde dehydrogenase Alcoholics Anonymous believes that alcoholism - ✔✔Is a disease and the only cure is total abstinence. Some critics say it gives alcoholics an "excuse". The process by which alcohol concentration is increased to more than 15%? - ✔✔distillation In most commercial beers today, alcohol content is a little over? - ✔✔4% Alcohol WD symptoms 6-24 hours after last drink. - ✔✔tremors, nausea, anxiety, irritablility insomnia, feelings of unreality convulsions hallucinations Thirty years ago, when people spoke of addiction they were most likely thinking of? - ✔✔Heroin The three basic processes related to the concept of addiction are? - ✔✔tolerance, physical dependence, reinforcement Tolerance refers to? - ✔✔The diminishing effect of a drug as a result of repeated exposure to the same dose of the drug. Withdrawal syndrome refers to? - ✔✔A set of consistent symptoms that appear when drug usage stops. The driving force behind narcotic addiction? - ✔✔The reinforcing effect of a drug on the brain rather than fear of withdrawal. In relation to physical dependence, psychological dependence is? - ✔✔A greater problem, since many addicts have gone through withdrawal will later relapse. ANOVA - ✔✔Factorial analysis of variance - used in the study of 2 or more variables. Most common is the 2x2 where there are 2 independent variables with each having 2 distinct values. Chemicals released from neurons (nerve cells) are called? - ✔✔neurotransmitters The neurotransmitter at the neuromuscular junctions in the somatic system is? - ✔✔acetylcholine - patients who die from Alzheimer has less than normal amount the basal ganglia is important for - ✔✔maintaining proper muscle tone Clonidine (Catapres) - ✔✔Used for opioid detoxification. Advantages of Clonidine over Methadone - ✔✔Does not produce opioid intoxication and is not reinforcing. Not classified as having abuse potential detox occurs w/o opioids no special licensing is required. Buprenorphine forms? - ✔✔Buprenex-injectable form Subutex-oral form (starting treatment) Suboxone-buprenorphine and nalxone(intedend for persons dependent on opioids who have already started and are continuing medication therapy.) Stimulants can produce at moderate doses? - ✔✔Wakefulness and a sense of well-being. Cocaine and amphetamines (methamphetamine) are the most frequently abused CNS stimulants. Opiates can produce at low doses? - ✔✔a relaxed dreamlike state Major tranquilizers are now referred to as? - ✔✔antipsychotics The safety margin of a drug is measured by the: - ✔✔difference between the effective dose level and the lowest toxic dose Drug absorption is most rapid when the intramuscular injection is given into the? - ✔✔deltoid muscle The fastest method by which the drug is delivered to the brain is? - ✔✔inhalation The reduced effect of a drug that may result from more rapid metabolism or excretion of the drug is referred to as? - ✔✔drug disposition tolerance Speedball is generally the combination of? - ✔✔heroin and cocaine In the 1960s, cocaine became popular again because? - ✔✔amphetamines became harder to obtain In South America, a popular way to use cocaine is? - ✔✔coca paste Crack? - ✔✔cocaine mixed with baking soda Cocaine's behavior effects are believed to depend on blocking the reuptake of? - ✔✔dopamine and serotonin A smokeable form of methamphetamine is referred to as? - ✔✔ice The current drug of choice for treating attention-deficit hyperactivity disorder (ADHD) is? - ✔✔methylphenidate(Ritalin) and dextroamphetamine (Dexedrine) - CNS stimulant most commonly abused along with opioids and CNS depressants. The most widely-used sedative-hypnotic drug is? - ✔✔alcohol Nonbarbiturate paraldehyde is not used because? - ✔✔has a noxious taste and odor Drugs used to induce sleep are called - ✔✔hypnotics A popular sedative that was introduced in 1960? - ✔✔Chlordiazepoxide(Librium)- benzodiazepine Meprobramate - ✔✔Anti-anxiety drug became very popular in the 1950's. Miltown, Equanil, Meprin - sedative and tranquilizer used to treat muscle tension and anxiety. Quaalude and Sopor were brand names for - ✔✔methaqualone- Schedule 1 drug Benzodiazepines - ✔✔Combined sales of the make them easily the most widely prescribed drug class. Flumazenil (Romazicon) acts at the receptor and reverses the sedative and overdose effects, but not alcohol or other sedative-hypnotics. The DSM-IV now refers to neurosis as? - ✔✔anxiety disorder Bipolar depression is a mood disorder? - ✔✔characterized by manic-depressive General paresis refers to? - ✔✔a syphilitic infection of the nervous system 1933 to help schizophrenic patients, Sakel used what? - ✔✔insulin Ugo Cerletti introduced electroconvulsive therapy (ECT) to treat? - ✔✔schizophrenia Phenothiazines are now referred to as? - ✔✔Antipsychotics Indivdiuals who use antipsychotic drugs may? - ✔✔exhibit photosensitivity and jaundice More than half of the prescribed antidepressants are prescribed by? - ✔✔non-psychiatrists Lithium was demonstrated to be effective on - ✔✔manic patients About how many homeless people in the US have some form of mental illness? - ✔✔33% "The way to tell whether a man is having drinking problems is to ask..." - ✔✔The BEST answer is "whether he has tried several times without success to reduce his drinking." What is the misconception of dependence potential for all psychoactive drugs? - ✔✔They are all not rated as "high". i.e. alcohol, marijuana, or hallucinogens they are moderate. When 2 or more psychoactive drugs are consumed together, the most serious risk from their "interaction" is? - ✔✔Respiration-Breathing, which can slow down to the point of starving the brain of oxygen. Blood pressure or circulation may also be at risk. BAC and metabolism in a standard drink has ½ ounce of ethanol, and the body eliminates ¼ ounce of ethanol per hour or 10-30 mg(.01-.03) - ✔✔"If you drink faster than one drink every two hours, your BAC will climb." Overall, the dependence risk from alcohol use? - ✔✔It is neither low nor high but moderate. When US deaths are classified and ranked according to the contributions of alcohol and other drugs, TOBACCO causes the most deaths, followed by alcohol, and then all other drugs. - ✔✔Some of the "all other drugs" are cocaine, heroin, and tranquilizers. Alcohol ranks SECOND after WHAT? - ✔✔tobacco and before drugs in annual deaths - after tobacco and other drugs analgesics - ✔✔Drugs used to relieve or eliminate pain acetylsalicylic acid - ✔✔the chemical known as aspirin antipyretic - ✔✔fever reducing NSAID - ✔✔nonsteroidal anti-inflammatory drugs, such as ibuprofen chlorpheniramine maleate - ✔✔a common antihistamine in cold products dextromethorphan - ✔✔an OTC antitussive (cough control) ingredient Antihistamines - ✔✔OTC sleep aids are based on __________ caffeine - ✔✔a bitter alkaloid found in coffee and tea that is responsible for their stimulating effects effects of caffeine - ✔✔stimulation, headaches and hyperactivity Xanthines - ✔✔the class of chemicals to which caffeine belongs adenosine - ✔✔inhibitory neurotransmitter through which caffeine acts time course of caffeine - ✔✔peak blood pressure at 30 minutes, peak CNS effects at 2 hours, half life is 3 hrs vivarin - ✔✔this stimulant drug contains 200mg of caffeine no doz - ✔✔this stimulant drug contains 100mg of caffeine theobromine - ✔✔a xanthine found in chocolate theophylline - ✔✔a xanthine found in tea cacao - ✔✔tropical tree whose seeds are used to make chocolate and cocoa cocoa - ✔✔powder of ground roasted cocao beans with most of the fat removed coca - ✔✔dried leaves of the coca plant (and related plants that also contain cocaine) Stimulant. caffeine intoxication and withdrawal - ✔✔intoxication: restlessness, incrrease diuresis, muscle twitching, arrhythmias withdrawal: Headache, lethargy, depression, weight gain Caffeine effect on brain - ✔✔Overall lower brain performance. It has been shown to be beneficial short term, but have long term bad effects if regularly used in large quantities. Caffeine effect on Pregnancy - ✔✔Having more than 300mg of caffeine each day can have a poor effect on a pregnancy; including spontaneous abortion, slow growth, birth defects etc. decaffeinated coffee - ✔✔Soaking unroasted beans in an organic solvent (methylene chloride) energy drinks - ✔✔These became a slightly lower caffeine content drink with about 80mg of caffeine each. i.e. red bull, rockstar, monster Caffeine most effective - ✔✔short-term in small doses and on a not-to-frequent basis. It also helps with performing physical activities that require a lot of energy (worse with mental activities) Nicotiana Tobacum - ✔✔The species of tobacco widely cultivated for smoking and chewing products Nicotiana rustica - ✔✔the less desirable species of tobacco, which is not widely grown in the United States Many screening instruments are available to detect the need for a full evaluation of a substance use disorder, including? - ✔✔SSI-SA - Simple Screening Instrument for Substance Abuse AUDIT - Alcohol Use Disorders Identification Test nitrosamines - ✔✔a type of chemical that is carcinogenic; several are found in tobacco leukoplakia - ✔✔a whitening and thickening of the mucous tissue in the mouth considered to be a precancerous tissue change. 85 - ✔✔__% of all lung cancers come from smoking 90 - ✔✔___% of nicotine is absorbed by the body through inhalation liver - ✔✔Nicotine is deactivated by the ______ nicotine poisoning - ✔✔symptoms often experienced by beginning smokers, including dizziness, diarrhea, light-headedness, rapid and erratic pulse, clammy skin, nausea, and vomiting emphysema - ✔✔a chronic lung disease characterized by difficulty breathing and shortness of breath proof - ✔✔a measure of a beverage's alcohol content; twice the alcohol percentage. ie 90 proof whiskey contains 45% alcohol French - ✔✔These people consume more alcohol per capita than any other nation and have the highest rates of alcohol dependence, suicide and deaths from cirrhosis of the liver. Withdrawal scales include? - ✔✔CIWA-Ar - Clinical Institute Withdrawal Assessment for alcohol withdrawal CINA - Clinical Institute Narcotic Assessment for opioid withdrawal. How many of the adult population label themselves as abstainers? - ✔✔1/3 % male drinkers % female drinkers % college students drinking past month - ✔✔60 45 62 Absorption of alcohol occurs where? - ✔✔Mostly the SI and stomach. Food and water slow the process. What is the BAC LD50? - ✔✔.40 or 400 mg/dL How many oz of alcohol can be metabolized an hour? - ✔✔.25 alcohol dehydrogenose - ✔✔enzyme converts alcohol to acetaldehyde(common by-product of breakdown of alcohol) blood alcohol concentration - ✔✔BAC- measured in milligrams (mg) of alcohol per deciliter (dL) of blood. 100 mg/dL = .1 percent Alcohol Myopia - ✔✔a condition that results when alcohol hampers attention, leading people to respond in simple ways to complex situations 40,000 - ✔✔This many fatalities related to alcohol each year. 2 general categories of Crises are? - ✔✔Developmental: One that occurs as a person experiences life, such as entering adolescence, getting married, having a baby, mid-life changes, retirement or the death of a spouse from natural causes in old age. Disturbing Event: accident, divorce, deaths, crime, financial losses, natural disasters or serious injuries. Alcohol related crime - ✔✔1/3 of suicides, 36-70% of homicides Wernicke-Korsakoff syndrome - ✔✔Chronic mental impairments produced by heavy alcohol use over a long period of time. Cirrhosis - ✔✔an irreversible, frequently deadly liver disorder associated with heavy alcohol use. Alcohol is associated with what cancers? - ✔✔Mouth, tongue, pharynx, larynx, esophagus, stomach, liver, lung, pancreas, colon and rectum. Heavy alcohol drinking is associated with? - ✔✔Heart Disease. Moderate drinkers have lower heart disease rates than total abstainers. detoxification - ✔✔an early treatment stage, in which the body eliminates the alcohol or other substance delirium tremens - ✔✔an alcohol withdrawal syndrome that includes hallucinations and tremors. Withdrawal Process - ✔✔1. tremors, heartbeat rapidity, sweating, loss of appetite, 2. hallucinations in many senses 3. delusions, disorientation, amnesia, delirium 4. seizures alcohol abuse - ✔✔a maladaptive pattern of use indicated by continued use despite knowledge of having persistent problems caused by alcohol alcohol dependence - ✔✔includes the physiological factors of tolerance and withdrawal when usage stops. Sedatives - ✔✔Drugs used to relax, calm or tranquilize. Barbiturates - amobarbital(Amytal), butabarbital(Butisol) other-buspirone(Buspar), meprobamate(Miltown) Hypnotics - ✔✔Drugs used to induce sleep. Barbiturates-pentobarbital(Nembutal), secobarbital(Seconal) other-chloral hydrate(Noctec,Somnos),