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ToxicMetals
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Toxic Metals •1) General introduction “Toxic Metals” •2) Chelators •3) Examples of Pb, As, Cd, Hg 2016 Nov 27 Chemistry 2211aͲ Toxic Metals Page 1 Toxic MetalsͲ Definition • Toxi... c – ‘Poisonous’ • Poison – is a chemical/physical agent that produces adverse responses (molecular, biochemical or physiological effects) in biological organisms • Toxic Metals – are metals that form poisonous compounds and may or may not have a biological role – Definition may include essential metals that are dangerous at abnormally high doses – Metals that coordinated to certain ligands become more accessible to the physiological chemistry Chemistry 2211aͲ Toxic Metals Page 2 Common Toxic Metals • Often are DͲblock metals • Metals on the RHS of the Periodic Table • Cu – high conc. toxic , Cr – oxidation state toxic Chemistry 2211aͲ Toxic Metals Page 3 The Toxicological Process Toxicokinetics:the quantitation of the time course of toxicants in the body Exposure Absorption Distribution & Metabolism of the toxicant Storage Excretion [Show More]
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