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Endocrine Lecture Notes

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• What is an endocrine hormone? How does it influence homeostasis vs. the nervous system. Acts more slowly than NS, NS acts quicker than the ES Has a longer term effect than NS, NS is moment to mo ... ment control Onset is slower but it last for longer amount of time, NS onset is quicker but lasts for a short amount of time uses chemical signals, uses chemical and electrical signals • The endocrine system helps maintain homeostasis as well as the nervous system • nervous system uses electrical and chemical signals but the endocrine system only uses chemical messengers. • nervous system is quicker, moment to moment adjustments • endocrine system is slower to respond, has long term affect • Endocrine glands are ductless glands that secretes product into the blood indirectly • into interstitial fluid —> blood • nervous system will trump the endocrine system because it works fast, specific, short term moment to moment, endocrine is slower • How can we make a hormone work better • Increase the number of receptors • increase the amount of hormone secreted • Increase temperature • Increase affinity of receptor • how tightly the hormone binds to the receptors, longer action and stronger affect • decrease degradation (extend the 1/2 life) • Half-life • the amount of time required before only half of the original product remains • determined by the chemical class • the ability to store hormone ( aa can be stored, blood levels don't reflect what our bodies are doing) • lipid soluble hormones have a higher half life than water soluble hormones • blood levels reflect our body’s ability to make them • It is hydrophobic because it doesn't get into our water/urine and get excreted as easily. • Stimulation • Stimulating the release of hormones can be • Neural: • suckling is going to cause sensory information to synapse on the paraventricular nuclei to release oxytocin • pain for vasopressin, which synapses on cells on the supraoptic nuclei • Hormonal • prolactin inhibiting hormone is going to bind to prolactinocytes which decreases prolactin production • Dopamine is going to inhibit prolactin • hormone binding which will cause a response • Humeral: • Blood osmolarity, blood pressure, glucose ....................................................................CONTINUED................................................... [Show More]

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