How are neurotransmitters deactivated when they are released in the synapse (hint: there are 2 different mechanisms)? Reuptake into presynaptic terminals or glial cells (ex. Amino acids-excitato ... ry amino acid transporters) Enzymatic degradation (ex. Acetylcholinestrase- AChE) What determines the effects of specific neurotransmitters (hint: it is NOT the neurotransmitter molecules)? Postsynaptic receptors determine the effects of neurotransmitters. What are neurotransmitter receptors? A membrane receptor protein that is activated by a neurotransmitter. What are different subtypes of NT receptors? Catecholaminergic o Dopamine o Norepinephrine o Epinephrine Amino Acidergic o Serotonin Cholinergic o Nicotinic, Muscarinic Glutamatergic o AMPA, Selective to Na+ o NMDA, Na+ K+ o Kainate o mGluR Serotonergic What are the different major types of NT receptors? (hint: we described two major types in class, but we discussed a total of 4 major types) Inotropic Metabotropic Enzyme-Linked Intracellular [Show More]
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