Deedra's dad has Alzheimer's Disease (AD) which is caused by a change in protein
structure
- True
Alzheimer's disease is caused by aggregation of the Amyloid beta peptide and tangle
formation by the tau protein. What
...
Deedra's dad has Alzheimer's Disease (AD) which is caused by a change in protein
structure
- True
Alzheimer's disease is caused by aggregation of the Amyloid beta peptide and tangle
formation by the tau protein. What kinds of amino acids are likely to drive the
formation of these protein aggregates?
- hydrophobic
After learning about Alzheimer's disease and one of the drugs used in its treatment,
what other drug design strategies could you use to offer treatment for AD?
- 1. Drugs that break up the amyloid plaques
2. Drugs that block the production of amyloid beta peptide
3. drugs that inhibits the aggregation of protein structures
A substrate binds to an enzyme at a specific site is referred to as
- an active site
You are in charge of designing a drug that inhibits the activity of a specific enzyme.
An important criteria for the drug selection is to ensure that the drug is directly in
competition with the original substrate when binding to the active site of the enzyme.
What inhibitor would be an ideal choice?
- A competitive inhibitor
These factors can affect the protein folding and activity of an enzyme:
- 1. pH
2. Heat
3. Reducing agents
One way a cell can avoid overproduction of a molecule is by using a particular type of
inhibition in which the molecule itself acts as an inhibitor for an enzyme in its
production pathway. This type of regulation is known as feedback inhibition
- True
What type of enzyme adds a phosphate to another molecule?
- Kinase
What are possible effects that phosphorylation/dephosphorylation can have on the
activity of an enzyme?
- 1. turn the enzyme on
2. turn the enzyme off
In the enzymatic cycle, the enzyme shape is changed when substrate binds and resumes
its original shape when product is released after substrate is converted to product.
- True
An enzyme increases the rate of a chemical reaction by:
- decreasing the activation energy
Compared to a patient that is not on a statin medication, In a patient taking a statin
medication the concentration of cholesterol would decrease, the concentration of
HMG-CoA would increase, and the concentration of Acetoacetyle CoA would stay the
same
- True
Primary structure consists of the order of amino acids in a protein. These are held
together with peptide bonds that are formed by a dehydration reaction.
- True
What types of chain interaction stabilize the tertiary structure of proteins, including:
- 1. ion pairs
2. hydrophobic interactions
3. hydrogen bonds
4. disulfide bonds
Secondary structure of proteins
- 1. It includes beta pleated sheet
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