CH 20 CANCER (PATHO FINAL)

CH 20 CANCER (PATHO FINAL) QUESTIONS AND ANSWERS What is a benign neoplasm originating from adipose tissue called? a. Adenoma b. Lipoma c. Fibrosarcoma d. Adenocarcinoma - ANS- lipoma What are malignant neoplasms ...

CH 20 CANCER (PATHO FINAL) QUESTIONS AND ANSWERS What is a benign neoplasm originating from adipose tissue called? a. Adenoma b. Lipoma c. Fibrosarcoma d. Adenocarcinoma - ANS- lipoma What are malignant neoplasms arising from connective tissue cells called? a. Carcinomas b. Sarcomas c. Melanomas d. Fibromas - ANS- sarcomas Which of the following is a characteristic of a benign tumor? a. It is unencapsulated and invasive. b. It consists of undifferentiated cells. c. It exerts systemic effects. d. Cells appear relatively normal. - ANS- cells appear relatively normal Which factor provides the basis for grading of newly diagnosed malignant tumors? a. size of the tumor b. number of metastases c. degree of differentiation of the cells d. number of lymph nodes involved - ANS- degree of differentiation of the cells A warning sign of possible cancer would be any of the following EXCEPT: a. persistent, unusual bleeding b. a change in bowel habits c. sudden development of fever, nausea, and diarrhea d. a change in shape, color, or surface of a skin lesion - ANS- a sudden development of fever, nausea, & diarrhea The common local effects of an expanding tumor mass include: 1. obstruction of a tube or duct 2. anemia and weight loss 3. cell necrosis and ulceration 4. tumor markers in the circulation - ANS- 1,3 -obstruction of a tube or duct -cell necrosis & ulceration Which of the following does paraneoplastic syndrome refer to? a. the effects of substances such as hormones secreted by the tumor cells b. severe weight loss and cachexia associated with advanced cancer c. the decreased resistance to infection resulting from malignant tumors d. the effects of multiple metastatic tumors - ANS- the effects of substances such as hormones secreted by the tumor cells Which term refers to the spread of malignant cells through blood and lymph to distant sites? a. invasiveness b. seeding c. metastasis d. systemic effect - ANS- metastasis One reason for staging a malignant tumor at the time of diagnosis is to: a. identify the original cell from which the tumor developed b. locate and identify the primary tumor c. decide the initiating factor for a particular tumor d. determine the best treatment and the prognosis - ANS- determine the best tx & prognosis The process of carcinogenesis usually begins with: a. exposure to promoters causing dysplasia b. development of defective genes c. an irreversible change in the cell DNA d. a single exposure to a known risk factor causing temporary cell damage - ANS- an irreversible change in the cell DNA What would be an external source of ionizing radiation? a. a needle containing a radioisotope implanted beside the tumor b. gamma rays delivered by a cobalt machine c. a dose of a radioactive drug to be ingested d. a fluid containing radioactive material instilled in a body cavity - ANS- gamma rays delivered by a cobalt machine Radiation therapy destroys: a. all cells in the tumor at one time b. the cells in the center of the tumor c. primarily rapidly dividing cells d. radioresistant cells - ANS- primarily rapidly dividing cells The most critical adverse effects of chemotherapy and radiation therapy are: a. thrombocytopenia and leucopenia b. headache and lethargy c. nausea and constipation d. alopecia and weight loss - ANS- thrombocytopenia & leucopenia Chemotherapy usually involves a combination of drugs in order to: 1. reduce the adverse effects 2. guarantee that all cancer cells are destroyed 3. be effective in more phases of the cell cycle 4. totally block the mitotic stage - ANS- 1 ,3 -reduce the adverse effects - be effective in more phases of the cell cycle Why does ovarian cancer have a poor prognosis? a. The ovaries are inaccessible for examination. b. Specific signs rarely appear until after secondary tumors have developed. c. The same tumor markers are present with many types of cancer. d. No effective treatment is available. - ANS- specific signs rarely appear until after secondary tumors have developed Select the correct pair representing a malignant tumor and its marker: a. colon cancer: carcinoembryonic antigen (CEA) b. hepatic cancer: CA125, AFP c. prostate cancer: human chorionic gonadotropin (hCG) d. testicular cancer: Philadelphia chromosome - ANS- colon cancer: carcinoembryonic antigen (CEA) Antiangiogenesis drugs act on a malignant tumor by: a. promoting the immune response and removal of abnormal tumor cells b. blocking hormonal stimulation of tumor cells c. reducing blood flow and nutrient supply to tumor cells d. transporting radioisotopes into the tumor - ANS- reducing blood flow & nutrient supply to tumor cells The development of neutropenia during chemotherapy for cancer means: a. the cancer cells are being destroyed quickly b. the patient is likely to hemorrhage c. higher doses of chemotherapy could be tolerated by this patient d. the patient is at high risk for infection - ANS- the pt is high risk for infection Malignant brain tumors: a. metastasize quickly to all parts of the body b. spread first to lungs and bone c. spread to other parts of CNS d. do not metastasize anywhere at any time - ANS- spread to other parts of the CNS Identify the common dose-limiting factor for chemotherapy: a. alopecia b. bone marrow depression c. nausea and vomiting d. weight loss - ANS- bone marrow depression Glucocorticoids are often prescribed during a course of chemotherapy and radiation because: a. glucocorticoids greatly potentiate the effect of chemotherapy b. the immune system is stimulated c. skeletal muscle atrophy will be decreased d. inflammation around the tumor may be reduced - ANS- inflammation around the tumor may be reduced Vomiting frequently follows a chemotherapy treatment because: a. the gastrointestinal tract is irritated b. the chemicals stimulate the emetic center c. the drugs have an unpleasant odor d. a, b e. a, c - ANS- a, b -the gasrointestinal tract is irritated -the chemical stimulate the emetic center What type of normal cells are often damaged during chemotherapy and radiation treatments?....