Q&A> Pharmaceutical Dosage Forms Laboratory Manual_PREPARATION # 3: PARACETAMOL TABLETS_Post Lab Questions: 1. Describe the mechanisms of action of the following materials? Give examples for
each.
a. diluents
- increa
...
Q&A> Pharmaceutical Dosage Forms Laboratory Manual_PREPARATION # 3: PARACETAMOL TABLETS_Post Lab Questions: 1. Describe the mechanisms of action of the following materials? Give examples for
each.
a. diluents
- increase the bulk of the formulation.
Example: mannitol, dicalcium phosphate, Lactose
b. binders/adhesives
- Granulator, “glue” powder together; Promotes cohesiveness; can be liquid or
solid.
Examples: Liquid – Glucose
Semi-solid – Starch paste
Solid – gelatin, sugar
c. disintegrants
- Helps in the break-up of the tablet after administration
Examples: Microcrystalline cellulose(Avicel), Sodium starch glycolate
d. lubricants
- Prevents adhesion of the tablet material to the surface of the punches and
dies
- Facilitates the ejection of the tablet from the die cavity
Example: Metallic stearates
Anti-adherents
- reduce the adhesion between the powder (granules) and the punch faces
and thus prevent sticking to tablet punches by offering a non-stick surface
Examples: gelatin, cellulose, cellulose derivatives
f. glidants
- improves the flow characteristic of the granule or powder mixture
- Added prior to compression to improve flow
Example: talc, colloidal silicon dioxide
g. colors/dyes
- Used to impart color to liquid and solid (e.g., tablets and capsules)
preparations
Examples: FD&C Red No.3. FD&C Red No. 20, FD&C Yellow No. 6
h. flavoring agents
- Gives natural or artificial tastes, which may include fragrances and colors of
the flavoring.
Examples: anise oil, cinnamon oil, cocoa, menthol
i. artificial sweeteners
- Sweeten food, beverages, medications, etc., such as sugar, saccharine or
other low-calorie synthetic products
Examples: aspartame, dextrose, glycerin, mannitol
2. Discuss briefly the classification of tablets based on methods/forms of manufacture.
- Wet granulation, dry granulation or direct compression are widely used to
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