*NURSING > Study Notes > MBC PURINES METABOLISM (All)
MBC PURINES METABOLISM
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PURINES 11. De novo and salvage pathways for purine nucleotides biosynthesis 2. Regulation of de novo biosynthesis of purine nucleotides 3. Degradation of purine nucleotides 4. Clinical significan... ce of purine nucleotides metabolism: Gout, drugs used in treatment of gout Severe combined Immunodeficiency (SCID) Lesch-Nyhan syndrome 5. Antimetabolites of purines nucleotides biosynthesis in cancer therapy; 6- Mercaptopurine, Azaserine, Folic acid analogs Outline 2Nucleoside and Nucleotide 3i. Precursors for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis ii. Components of coenzymes such as NAD(H), NADP(H), FMN(H2), Coenzyme A iii. Source of energy driving many metabolic processes e.g ATP, GTP iv. Carriers in biosynthesis e,g UDP for carbohydrates and CTP for lipids (UDP-glucose, CDP-diacylglycerol) v. Cellular second messengers e.g cAMP, cGMP Roles of nucleotides in cell physiology 4Nucleotides can be synthesized through the : De novo pathway from basic metabolites/ simple precursors Salvage pathway from existing bases (recycle preformed bases / from products of DNA and RNA degradation) [Show More]
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