Business > CASE STUDY > Diuretics.edited.docx NURS 615 Diuretics – Clinical Pharmacology in Diuretic Use Mary (All)
Diuretics.edited.docx NURS 615 Diuretics – Clinical Pharmacology in Diuretic Use Mary
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Diuretics.edited.docx NURS 615 Diuretics – Clinical Pharmacology in Diuretic Use Maryville University NURS 615: Advanced Pharmacotherapeutics Diuretics The article by Ellison (2019) exami... nes the pharmacokinetics and pharmacodynamics of diuretic drugs. Although diuretics have various medical uses, the article focuses on their role in the treatment of extracellular fluid volume expansion and edema. Diuretics are classified according to the targeted site of action in the nephron and the mechanisms in which they inhibit transportation. The main classes of diuretics include loop diuretics, distal convoluted tubule diuretics, and potassium-sparing diuretics. Loop diuretics include furosemide, bumetanide, and torsemide (Ellison, 2019). The loop diuretics are absorbed relatively quickly when administered orally, and they have an instantaneous therapeutic effect when administered intravenously. The volumes of distribution for loop diuretics are generally low, mainly because the diuretics are tightly bonded with albumin. In this case, severe hypoalbuminemia could affect the effectiveness of loop diuretics. About 50 % of the administered furosemide is excreted unchanged through the urine (Ellison, 2019). However, most loop diuretics are eliminated through hepatic processes and urinary excretion. Loop diuretics have a relatively short half-life. When using diuretics to treat edema, it is essential to ascertain that the dose provides a tubule concentration exceeding the threshold. Loop diuretics ex. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .. .. . . . . . . . . . . . . . . . . . .. . . . . [Show More]
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