Business > CASE STUDY > Week 5 ATI report and analysis.docx NR 293 Administration of Alteplase to Combat a Strok (All)
Week 5 ATI report and analysis.docx NR 293 Administration of Alteplase to Combat a Strok
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Week 5 ATI report and analysis.docx NR 293 Administration of Alteplase to Combat a Stroke Chamberlain College of Nursing NR 293 – Pharmacology Alteplase is a thrombolytic agent approved ... for pulmonary embolism, myocardial infarction, and ischemic stroke (Reed, Kerndt, & Nicolas, 2020). Alteplase is also known as a tissue plasminogen activator, tPA. The way tPA works due to plasminogen converting to plasmin; this results in a lysis formation. Alteplase is only available in an IV form. The administration starts by giving a bolus of 10% of the total dose over one minute, then the remaining amount id administered over the next 60 minutes (Reed, Kerndt, & Nicolas, 2020). To be most effective, the patient needs to receive this medication as soon as possible and needs to be within 3 – 4.5 hours of the onset of symptoms. Before administration, blood work should be taken, including a CBC, aPTT, and a serum fibrinogen test; these should be repeated after alteplase therapy (Reed, Kerndt, & Nicolas, 2020). The nurse also needs to obtain a set of vitals, including a neurological assessment before administration then should periodically check the patients' vital signs and neurological status throughout the infusion. Since alteplase is used to "bust" a clot, resulting in anticoagulation, resulting in the thinning of the blood, there are some severe contraindications. The usage of tPA is contraindicated and should be avoided in individuals with any hemorrhage, internal bleeding, severe uncontrolled hypertension, and. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .. .. . . . . . . . . . . . . . . . . . .. . . . . [Show More]
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