BioChemistry > STUDY GUIDE > BIOL 3362/CHEM 3362 - BIOCHEMISTRY II EXAM 4 STUDY GUIDE (All)
BIOL 3362/CHEM 3362 - BIOCHEMISTRY II EXAM 4 STUDY GUIDE
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BIOL 3362/CHEM 3362 - BIOCHEMISTRY II EXAM 4 STUDY GUIDE• How is malonyl-CoA formed? The action of Acetyl-CoA Carboxylase, which is the rate limiting enzyme for FA synthesis, converts Acetyl-CoA ... to Malonyl-CoA through condensation with CO2 and hydrolysis of an ATP. This is a 2-step irreversible, committed step in FA biosynthesis. Malonyl-CoA is then used further for FA synthesis by extending the Acyl-CoA chain to ultimately form Palmitic Acid, a 16-carbon saturated fatty acid. • What is the function of biotin in fatty acid synthesis? Biotin is a prosthetic group on Acetyl-CoA Carboxylase that allows for carboxylation of AcetylCoA to form Malonyl-CoA. Step 1 of the reaction involves formation of an N-Carboxy Biotin intermediate that is formed through a transient carbonyl phosphate. Step 2 involves nucleophilic attack by Acetyl-CoA carbanion on the carboxy cation of N-carboxybiotin to form Malonyl-CoA. Biotin is linked to the enzyme by a lysine residue on the Biotin Carboxyl Carrier Protein Subunit (BCCP). This study source was downloaded by 100000829247859 from CourseHero.com on 08-05-2021 18:44:41 GMT -05:00 https://www.coursehero.com/file/79711670/BIOL-3362-Exam-4-Study-Guidedocx/ This study resource was shared via Co [Show More]
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